Licensure follows the patient
The location that matters for telehealth is generally the patient’s, not yours. Sitting in one state and caring for a patient in South Carolina generally means you need authority to practice in South Carolina — via compact privilege or a South Carolina license. See telehealth: patient in another state.
The law that governs this in South Carolina
Caring for a patient located in South Carolina is practice in South Carolina, so it is South Carolina’s own nurse practice act that defines what you may do and the South Carolina Board of Nursing that applies it. That act is S.C. Code tit. 40, ch. 33 (Nurses); discipline at § 40-33-110.
The compact itself is separate law. South Carolina adopted it at S.C. Code Ann. §§ 40-33-1300 to 40-33-1365 (tit. 40, ch. 33, art. 15 — Nurse Licensure Compact), which is what allows a multistate license issued elsewhere to reach South Carolina at all — the practice act still decides what you may do once it does.
Compact status is not the only consideration
Even where a multistate license reaches South Carolina, your employer and the South Carolina Board of Nursing may impose additional requirements, and some roles carry their own rules. Compact status answers one question — it is not a blanket authorization to practice remotely.
APRN telehealth is separate
The compact covers RN and LPN/LVN licenses only. If you work as an APRN, your advanced-practice authority is granted state by state and is not carried by a multistate RN license — a point that catches out a lot of remote NP roles.
Since when has a compact license worked in South Carolina?
Nurses holding another state’s multistate license have been able to practice in South Carolina since January 19, 2018. It has been a member long enough that most guidance you find will be accurate on this point.