Licensure follows the patient
The location that matters for telehealth is generally the patient’s, not yours. Sitting in one state and caring for a patient in Mississippi generally means you need authority to practice in Mississippi — via compact privilege or a Mississippi license. See telehealth: patient in another state.
The law that governs this in Mississippi
Caring for a patient located in Mississippi is practice in Mississippi, so it is Mississippi’s own nurse practice act that defines what you may do and the Mississippi Board of Nursing that applies it. That act is Miss. Code Ann. § 73-15-1 et seq. (Mississippi Nursing Practice Law).
The compact itself is separate law. Mississippi adopted it at Miss. Code Ann. § 73-15-201 (Nurse Licensure Compact), which is what allows a multistate license issued elsewhere to reach Mississippi at all — the practice act still decides what you may do once it does.
Compact status is not the only consideration
Even where a multistate license reaches Mississippi, your employer and the Mississippi Board of Nursing may impose additional requirements, and some roles carry their own rules. Compact status answers one question — it is not a blanket authorization to practice remotely.
APRN telehealth is separate
The compact covers RN and LPN/LVN licenses only. If you work as an APRN, your advanced-practice authority is granted state by state and is not carried by a multistate RN license — a point that catches out a lot of remote NP roles.
Since when has a compact license worked in Mississippi?
Nurses holding another state’s multistate license have been able to practice in Mississippi since January 19, 2018. It has been a member long enough that most guidance you find will be accurate on this point.